DISEASES

Disease-gene associations mined from literature

Literature associating PBK and malignant peripheral nerve sheath tumor

PBK [ENSP00000428489]

Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Synonyms:  PBK,  E5RFX4,  E5RIE1,  HEL164,  Q96KB5 ...

Linkouts:  STRING  Pharos  UniProt