Literature associating SPSB2 and congenital muscular dystrophy-dystroglycanopathy A7
SPSB2 [ENSP00000428338]
SPRY domain-containing SOCS box protein 2; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 .
Synonyms: SPSB2, SPSB2p, hSPSB2, E5RIC2, Q99619 ...