DISEASES

Disease-gene associations mined from literature

Literature associating RAD17 and Warsaw breakage syndrome

RAD17 [ENSP00000426191]

Cell cycle checkpoint protein RAD17; Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112,; Belongs to the rad17/RAD24 family.

Synonyms:  RAD17,  RAD17p,  hRAD17,  D6RA84,  D6RAW6 ...

Linkouts:  STRING  Pharos  UniProt