Literature associating MIB2 and high grade ependymoma
MIB2 [ENSP00000426103]
E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Synonyms: MIB2, MIB2p, hMIB2, D6R9Q6, D6RAZ0 ...