DISEASES

Disease-gene associations mined from literature

Literature associating ATPSCKMT and pulmonary subvalvular stenosis

ATPSCKMT [ENSP00000422338]

ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration . Promotes chronic pain . Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia .

Synonyms:  ATPSCKMT,  D6RBE3,  D6RIE0,  J3KN90,  Q6P4H8 ...

Linkouts:  STRING  Pharos  UniProt