DISEASES

Disease-gene associations mined from literature

Literature associating FNIP1 and kidney benign neoplasm

FNIP1 [ENSP00000421985]

Folliculin-interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways . May regulate phosphorylation of RPS6KB1 . ; Belongs to the FNIP family.

Synonyms:  FNIP1,  FNIP1p,  hFNIP1,  A0A087WX11,  J3KNG8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM