Literature associating SELENOK and Keshan disease
SELENOK [ENSP00000418813]
Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function . Plays a role in protection of cells from ER stress- induced apoptosis . Protects cells from oxidative stress when overexpressed in cardiomyocytes . ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385,
Synonyms: SELENOK, F6XHT0, F8WAX7, Q9Y6D0, F6XHT0p ...