DISEASES

Disease-gene associations mined from literature

Literature associating MCM10 and Rothmund-Thomson syndrome

MCM10 [ENSP00000418268]

Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 . ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597,; Belongs to the MCM10 family.

Synonyms:  MCM10,  MCM10p,  hMCM10,  C9J600,  Q5T670 ...

Linkouts:  STRING  Pharos  UniProt