DISEASES

Disease-gene associations mined from literature

Literature associating SUPT20H and age related macular degeneration 8

SUPT20H [ENSP00000417510]

Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. ; Belongs to the SPT20 family.

Synonyms:  SUPT20H,  SUPT20Hp,  hSUPT20H,  A0A024RDW2,  B4E2D5 ...

Linkouts:  STRING  Pharos  UniProt