DISEASES

Disease-gene associations mined from literature

Literature associating SPATA2 and otulipenia

SPATA2 [ENSP00000416799]

Spermatogenesis-associated protein 2; Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis . Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) . Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD . Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27545878,

Synonyms:  SPATA2,  SPATA2p,  hSPATA2,  Q9UM82,  Q9UM82p ...

Linkouts:  STRING  Pharos  UniProt