DISEASES

Disease-gene associations mined from literature

Literature associating CFB and membranoproliferative glomerulonephritis

CFB [ENSP00000416561]

Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Synonyms:  CFB,  A0A1U9X7H8,  C9JRT3,  F8WBL9,  H7C526 ...

Linkouts:  STRING  Pharos  UniProt