DISEASES

Disease-gene associations mined from literature

Literature associating SEMA4D and Hantavirus hemorrhagic fever with renal syndrome

SEMA4D [ENSP00000416523]

Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling . Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA . Promotes the migration of cerebellar granule cells . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway . ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282,; Belongs to the semaphorin family.

Synonyms:  SEMA4D,  SEMA4Dp,  hSEMA4D,  A0A0C4DG45,  C9JD54 ...

Linkouts:  STRING  Pharos  UniProt