DISEASES

Disease-gene associations mined from literature

Literature associating COLEC11 and urinary schistosomiasis

COLEC11 [ENSP00000411770]

Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis . Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope . Primarily recognizes the terminal disaccharide of the glycan . Also recognizes a subset of fucosylated glycans and lipopolysaccharides . Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 . Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis . ECO:0000269|PubMed:21258343, ECO:0000269|PubMed:23954398, ECO:0000269|PubMed:25912189, ECO:0000269|PubMed:28301481,; Belongs to the COLEC10/COLEC11 family.

Synonyms:  COLEC11,  COLEC11p,  hCOLEC11,  C9JWT5,  F8WB29 ...

Linkouts:  STRING  Pharos  UniProt