Literature associating GLRA1 and Unverricht-Lundborg syndrome
GLRA1 [ENSP00000411593]
Glycine receptor subunit alpha-1; Glycine receptors are ligand-gated chloride channels . Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta- alanine . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Channel activity is potentiated by ethanol . Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:25730860, ECO:0000269|PubMed:25973519, ECO:0000269|PubMed:7920629, ECO:0000269|PubMed:7925268,
Synonyms: GLRA1, GLRA1p, hGLRA1, E5RJ70, P23415 ...