DISEASES

Disease-gene associations mined from literature

Literature associating AFAP1 and Cronkhite-Canada syndrome

AFAP1 [ENSP00000410689]

Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Synonyms:  AFAP1,  AFAP1p,  hAFAP1,  A0A087X177,  Q8N556 ...

Linkouts:  STRING  Pharos  UniProt