DISEASES

Disease-gene associations mined from literature

Literature associating FBP1 and fructose-1,6-bisphosphatase deficiency

FBP1 [ENSP00000408025]

Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Synonyms:  FBP1,  FBP1p,  hFBP1,  A0A3B3IUC7,  P09467 ...

Linkouts:  STRING  Pharos  UniProt