DISEASES

Disease-gene associations mined from literature

Literature associating UNC45A and GNE myopathy

UNC45A [ENSP00000407487]

Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Synonyms:  UNC45A,  UNC45Ap,  hUNC45A,  A0A1W2PNX8,  Q9H3U1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM