DISEASES

Disease-gene associations mined from literature

Literature associating TAF1 and hemidystonia

TAF1 [ENSP00000406549]

Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex . Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity . Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 . ECO:0000269|PubMed:15870300, ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:25412659, ECO:0000269|PubMed:27007846, ECO:0000269|PubMed:8450888, ECO:0000269|PubMed:8625415,; Belongs to the TAF1 family.

Synonyms:  TAF1,  TAF1p,  hTAF1,  H0Y8N6,  H0Y9L7 ...

Linkouts:  STRING  Pharos  UniProt