DISEASES

Disease-gene associations mined from literature

Literature associating TCEA3 and hereditary spastic paraplegia 34

TCEA3 [ENSP00000406293]

Transcription elongation factor A protein 3; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Synonyms:  TCEA3,  TCEA3p,  hTCEA3,  O75764,  S4R3M9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM