DISEASES

Disease-gene associations mined from literature

Literature associating ENPP3 and co-trimoxazole allergy

ENPP3 [ENSP00000406261]

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP . Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity .

Synonyms:  ENPP3,  ENPP3p,  hENPP3,  E7ETI7,  E9PDB4 ...

Linkouts:  STRING  Pharos  UniProt