DISEASES

Disease-gene associations mined from literature

Literature associating UNC5C and SATB2-associated syndrome

UNC5C [ENSP00000406022]

Netrin receptor UNC5C; Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity); Belongs to the unc-5 family.

Synonyms:  UNC5C,  UNC5Cp,  hUNC5C,  A0A087X152,  D6RE16 ...

Linkouts:  STRING  Pharos  UniProt  OMIM