Literature associating SLC4A8 and familial febrile seizures 6
SLC4A8 [ENSP00000405812]
Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
Synonyms: SLC4A8, SLC4A8p, hSLC4A8, Q2Y0W8, Q2Y0W8p ...