DISEASES

Disease-gene associations mined from literature

Literature associating CRYZ and hypertrophic cardiomyopathy 2

CRYZ [ENSP00000399805]

Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Synonyms:  CRYZ,  A6NP24,  C9JH92,  Q08257,  A6NP24p ...

Linkouts:  STRING  Pharos  UniProt