DISEASES

Disease-gene associations mined from literature

Literature associating POLDIP3 and methylmalonic acidemia cblB type

POLDIP3 [ENSP00000397927]

Polymerase delta-interacting protein 3; Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.

Synonyms:  POLDIP3,  POLDIP3p,  hPOLDIP3,  F6VRR5,  F8WCX5 ...

Linkouts:  STRING  Pharos  UniProt