DISEASES

Disease-gene associations mined from literature

Literature associating TENT2 and Perlman syndrome

TENT2 [ENSP00000397563]

Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs . Does not play a role in replication-dependent histone mRNA degradation . Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs ; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.

Synonyms:  TENT2,  TENT2p,  hTENT2,  D6RAF2,  Q6PIY7 ...

Linkouts:  STRING  Pharos  UniProt