Literature associating GRIK2 and autosomal recessive intellectual developmental disorder
GRIK2 [ENSP00000397026]
Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist . May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).
Synonyms: GRIK2, GRIK2p, hGRIK2, A0A0A0MR30, A0A0A0MRL4 ...