Literature associating CORO1C and coronin-1A deficiency
CORO1C [ENSP00000394496]
Coronin-1C; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells . Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum- associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission . Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane . Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950,; Belongs to the WD repeat coronin family.
Synonyms: CORO1C, CORO1Cp, hCORO1C, A0A024RBI5, B4E3S0 ...