DISEASES

Disease-gene associations mined from literature

Literature associating ACE2 and renal hypertension

ACE2 [ENSP00000389326]

Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator . Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency . By cleavage of angiotensin II, may be an important regulator of heart function . By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity . ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, (Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63.

Synonyms:  ACE2,  ACE2p,  hACE2,  Q9BYF1,  Q9BYF1p ...

Linkouts:  STRING  Pharos  UniProt