DISEASES

Disease-gene associations mined from literature

Literature associating TSTD1 and ethylmalonic encephalopathy

TSTD1 [ENSP00000388293]

Thiosulfate:glutathione sulfurtransferase; Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism . Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate . The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor .

Synonyms:  TSTD1,  TSTD1p,  hTSTD1,  Q8NFU3,  R4GNF9 ...

Linkouts:  STRING  Pharos  UniProt