Literature associating SLC12A5 and idiopathic generalized epilepsy 14
SLC12A5 [ENSP00000387694]
Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation .
Synonyms: SLC12A5, SLC12A5p, hSLC12A5, A0A087X201, A0A0D9SF89 ...