DISEASES

Disease-gene associations mined from literature

Literature associating CIAO2B and xeroderma pigmentosum group D

CIAO2B [ENSP00000387471]

Cytosolic iron-sulfur assembly component 2B; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins . As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD . ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362,; Belongs to the MIP18 family.

Synonyms:  CIAO2B,  CIAO2Bp,  hCIAO2B,  H3BNV7,  J3KS95 ...

Linkouts:  STRING  Pharos  UniProt  OMIM