Literature associating NLRX1 and mitochondrial complex III deficiency nuclear type 5
NLRX1 [ENSP00000387334]
NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction . Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 . Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis . Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species .
Synonyms: NLRX1, NLRX1p, hNLRX1, C9J0R6, C9JLK8 ...