DISEASES

Disease-gene associations mined from literature

Literature associating NOTUM and permanent neonatal diabetes mellitus

NOTUM [ENSP00000387310]

Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors .

Synonyms:  NOTUM,  C9JYG8,  K7EIG3,  Q6P988,  C9JYG8p ...

Linkouts:  STRING  Pharos  UniProt  OMIM