Literature associating TRABD2A and janus kinase-3 deficiency
TRABD2A [ENSP00000387075]
Metalloprotease TIKI1; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Synonyms: TRABD2A, LOC105374836, TRABD2Ap, hTRABD2A, C9IYB5 ...