DISEASES

Disease-gene associations mined from literature

Literature associating PLD3 and Nasu-Hakola disease

PLD3 [ENSP00000387050]

5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) . Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation . Plays a role in lysosomal homeostasis . Involved in the regulation of endosomal protein sorting . ECO:0000269|PubMed:22428023, ECO:0000269|PubMed:28128235,

Synonyms:  PLD3,  PLD3p,  hPLD3,  A0A024R0Q4,  A0A0A0MS28 ...

Linkouts:  STRING  Pharos  UniProt