DISEASES

Disease-gene associations mined from literature

Literature associating DUSP28 and Sveinsson chorioretinal atrophy

DUSP28 [ENSP00000385885]

Dual specificity phosphatase 28; Has phosphatase activity with the synthetic substrate 6,8- difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine . The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.

Synonyms:  DUSP28,  DUSP28p,  hDUSP28,  H7C234,  Q4G0W2 ...

Linkouts:  STRING  Pharos  UniProt