DISEASES

Disease-gene associations mined from literature

Literature associating TNFSF18 and immunodeficiency 16

TNFSF18 [ENSP00000385470]

Tumor necrosis factor ligand superfamily member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T- cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 . Promotes leukocyte adhesion to endothelial cells . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044,; Belongs to the tumor necrosis factor family.

Synonyms:  TNFSF18,  TNFSF18p,  hTNFSF18,  A0A0U5JXL4,  Q9UNG2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM