DISEASES

Disease-gene associations mined from literature

Literature associating SOS1 and Noonan syndrome with multiple lentigines

SOS1 [ENSP00000384675]

Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP . Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF . Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).

Synonyms:  SOS1,  SOS1p,  hSOS1,  C9K0N6,  G5E9C8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM