DISEASES

Disease-gene associations mined from literature

Literature associating HYPK and writing disorder

HYPK [ENSP00000384474]

Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT . Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells . Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex . Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation . However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N- terminal acetylation .

Synonyms:  HYPK,  A0A024R5Q1,  J3QT56,  Q9NX55,  J3QT56p ...

Linkouts:  STRING  Pharos  UniProt