DISEASES

Disease-gene associations mined from literature

Literature associating CDCA7L and malignant pineal area germ cell neoplasm

CDCA7L [ENSP00000383986]

Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38- kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Synonyms:  CDCA7L,  CDCA7Lp,  hCDCA7L,  A0A024RA51,  C9IZR6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM