DISEASES

Disease-gene associations mined from literature

Literature associating CTNND1 and pulmonary sclerosing hemangioma

CTNND1 [ENSP00000382004]

Catenin delta-1; Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics . Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors . ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476,; Belongs to the beta-catenin family.

Synonyms:  CTNND1,  CTNND1p,  hCTNND1,  A0A024R4Y7,  A0A024R4Z0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM