DISEASES

Disease-gene associations mined from literature

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Literature associating LCP1 and orbital granuloma

LCP1 [ENSP00000381581]

Plastin-2; Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 . Modulates the cell surface expression of IL2RA/CD25 and CD69 .

Synonyms:  LCP1,  LCP1p,  hLCP1,  A0A024RDT4,  P13796 ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.