DISEASES

Disease-gene associations mined from literature

Literature associating CTDSP2 and acute tympanitis

CTDSP2 [ENSP00000381148]

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Synonyms:  CTDSP2,  CTDSP2p,  hCTDSP2,  A0A024RBA6,  F8VYL0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM