DISEASES

Disease-gene associations mined from literature

Literature associating ASCC2 and photosensitive trichothiodystrophy

ASCC2 [ENSP00000380877]

Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains . Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation .

Synonyms:  ASCC2,  ASCC2p,  hASCC2,  A0A024R1F9,  B1AH59 ...

Linkouts:  STRING  Pharos  UniProt