DISEASES

Disease-gene associations mined from literature

Literature associating IL15RA and ACTH-independent macronodular adrenal hyperplasia 1

IL15RA [ENSP00000380421]

Soluble interleukin-15 receptor subunit alpha; High-affinity receptor for interleukin-15 . Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation . In neutrophils, required for IL15- induced phagocytosis in a SYK-dependent manner . Expression of different isoforms may alter or interfere with signal transduction . ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:15123770, [Isoform 6]: Does not bind IL15. [Isoform 8]: Does not bind IL15.

Synonyms:  IL15RA,  IL15RAp,  hIL15RA,  A0A0A0MS77,  E7ETI1 ...

Linkouts:  STRING  Pharos  UniProt