Literature associating GNE and isolated elevated serum creatine phosphokinase levels
GNE [ENSP00000379839]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells; In the C-terminal section; belongs to the ROK (NagC/XylR) family.
Synonyms: GNE, Q9Y223, Q9Y223p, hQ9Y223, 10020 ...