DISEASES

Disease-gene associations mined from literature

Literature associating RAB27A and choroid disease

RAB27A [ENSP00000379601]

Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion . Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

Synonyms:  RAB27A,  RAB27Ap,  hRAB27A,  A2RU94,  H3BN55 ...

Linkouts:  STRING  Pharos  UniProt