DISEASES

Disease-gene associations mined from literature

Literature associating TNRC6A and cervical non-keratinizing squamous cell carcinoma

TNRC6A [ENSP00000379144]

Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672,

Synonyms:  TNRC6A,  TNRC6Ap,  hTNRC6A,  H3BRT3,  H3BTQ1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM