Literature associating DAAM1 and ITM2B-related cerebral amyloid angiopathy 2
DAAM1 [ENSP00000378557]
Disheveled-associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia . Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). ; Belongs to the formin homology family.
Synonyms: DAAM1, DAAM1p, hDAAM1, G3V275, Q9Y4D1 ...