DISEASES

Disease-gene associations mined from literature

Literature associating DAAM1 and ITM2B-related cerebral amyloid angiopathy 2

DAAM1 [ENSP00000378557]

Disheveled-associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia . Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). ; Belongs to the formin homology family.

Synonyms:  DAAM1,  DAAM1p,  hDAAM1,  G3V275,  Q9Y4D1 ...

Linkouts:  STRING  Pharos  UniProt