DISEASES

Disease-gene associations mined from literature

Literature associating GRM2 and cocaine dependence

GRM2 [ENSP00000378492]

Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762,

Synonyms:  GRM2,  GRM2p,  hGRM2,  C9JD41,  C9JL63 ...

Linkouts:  STRING  Pharos  UniProt  OMIM